Tofranil (Imipramine)

Usage and Class

Imipramine was the first tricyclic antidepressant to be developed and is used for treating depression manifestations. Imipramine affects numerous systems involved in the etiology of anxiety, depression, and other mental conditions.

Safety and Additional Info

This drug may cause certain side-effects, particularly with the first few doses. Your family or other close people should pay special attention to changes in your mood. There is a possibility of suicide inclination, especially in patients less than 24 years old.

Dose correction may be needed if side effects are severe or suicidal thoughts persist. Be ready for regular visits of a healthcare professional during the first three months of treatment.

Contra-Indications

Be sure to tell your doctor about possible allergic reactions to Imipramine and your history of heart problems and heart attacks. Imipramine is definitely not compatible with MAO inhibitors including Azilect (rasagiline), Eldepryl (selegiline), Marplan (isocarboxazid), Nardil (phenelzine), Parnate (tranylcypromine). A break of not less that two weeks is needed after taking a MAO inhibitor. Otherwise, a life-threatening condition may occur.

In some cases additional tests and dose corrections will be needed for your complete safety. Tell your physician about any of the cases listed here if they apply to you: urination problems, diabetes, pheochromocytoma, bipolar disorder, heart problems, glaucoma, heart attack or stroke, liver or kidney problems, overactive thyroid.

Seek for medical help immediately in case your condition persists or even worsens. Mood or behavior changes, suicide inclinations, anxiety and panic; problems with sleep, abnormal feelings (irritation, agitation, impulsiveness, aggression, hyperactivity) are the signs that you need additional consultations and help.

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