Antacid and Reflux Drugs: Pro-motility Drugs
Metoclopramide (Reglan)
HOW DOES THIS DRUG WORK?
Metoclopramide (Reglan) is one in the class of pro-motility drugs approved for GERD. It works by mildly increasing the pressure in the lower esophageal sphincter, which strengthens contractions of the esophagus and speeds up emptying of the stomach. All these actions are thought to reduce reflux. It is most effective when taken 30 minutes before meals.
WHAT ARE THE BENEFITS?
This drug reduces symptoms of GERD. It is not very effective for treating the symptoms of GERD, however, and is usually prescribed as an addition to other GERD medications or for those who do not respond to common GERD medications.
POTENTIAL SIDE EFFECTS
- Nausea
- Diarrhea
- Headache
- Dizziness
- Drowsiness
- Dry mouth
- Restlessness
- Involuntary movements of the eyes/face/limbs
- Muscle spasms
- Trembling of the hands
- Personality changes such as depression or thoughts of suicide
- High fever
- Sweating
- Muscle stiffness
- Confusion
- Unusually fast heartbeat
