Posts Tagged ‘interactions’

Nonstimulants Drugs for Treatment Attention Deficit Hyperactivity Disorder

Sunday, August 29th, 2010

Nonstimulants Drugs for Treatment Attention Deficit Hyperactivity Disorder.

The only currently existing, approved nonstimulant ADHD medication is atomoxetine (Strattera).

HOW DOES THIS DRUG WORK?

Strattera is a selective norepinephrine reuptake inhibitor, which essentially means it increases the activity of the brain chemical (or neurotransmitter) norepinephrine. More norepinehrine is thought to increase attention and control hyperactivity and impulsivity in ADHD.

WHAT ARE THE BENEFITS?

The effectiveness of Strattera in the treatment of ADHD was established in four studies of pediatric patients ages 6 to 18. Compared with placebo, Strattera proved to be superior with respect to reducing impulsiveness, hyperactivity, and inattention. The effectiveness of Strattera for long-term use (for more than nine weeks) in child and adolescent patients has not been thoroughly evaluated.

POTENTIAL SIDE EFFECTS

Common side effects are loss of appetite, drowsiness, headache, stomachache, nausea, vomiting, dizziness, dry mouth, diarrhea, constipation, difficulty sleeping, sexual dysfunction, agitation, irritability, and difficulty urinating.

MAJOR CAUTIONS (more…)

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Atherosclerosis and CAD Drugs Nitrates

Tuesday, July 27th, 2010

Atherosclerosis and CAD Drugs Nitrates

  • Isosorbide dinitrate, sublingual and chewable (Isordil, Sorbitrate)
  • Isosorbide mononitrate (Imdur, Ismo, Isotrate ER,Monoket)
  • Nitroglycerin ER (Nitroglyn)
  • Nitroglycerin ointment (Nitro-Bid ointment, Nitrol)
  • Nitroglycerin skin patches (Deponit, Minitran, Nitro-Dur, Nitrodisc,
  • Transderm-Nitro)
  • Nitroglycerin spray (Nitrolingual)

How do these drugs work?

This class of medications dilates the veins returning blood to the heart as well as the heart arteries, increasing oxygenation of the heart cells.

What are the benefits?

Quick relief of heart pain (angina)

Potential side effects

  • Constant throbbing headache
  • Flushing of the head and neck
  • Increased heart rate or heart palpitations
  • Nausea, vomiting

Major cautions

Drop in blood pressure, causing dizziness and weakness

Known drug interactions (more…)

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Anxiety Drugs Monoamine Oxidase Inhibitors (MAOIs)

Friday, June 11th, 2010

Anxiety Drugs Monoamine Oxidase Inhibitors (MAOIs)

  • Isocarboxazid (Marplan)
  • Phenelzine (Nardil)
  • Tranylcypromine (Parnate)

HOW DO THESE DRUGS WORK?

This group of antidepressants has been used since the 1950s. They increase the brain

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Anxiety Drugs Selective Serotonin and Norepinephrine

Friday, June 4th, 2010

Anxiety Drugs Selective Serotonin and Norepinephrine

  • Reuptake Inhibitors (SNRIs)
  • Duloxetine (Cymbalta)
  • Venlafaxine (Effexor)

HOW DO THESE DRUGS WORK?

SNRIs work mainly by increasing the amounts of two neurotransmitters in the brain, serotonin and norepinephrine. This improves alertness, energy, mood, and motivation.

WHAT ARE THE BENEFITS?

These drugs can be effective for severe and chronic cases of depression.

POTENTIAL SIDE EFFECTS

  • Abdominal (stomach) pain or tenderness
  • Itching
  • Rash
  • Dry mouth
  • Constipation
  • Dizziness
  • Drowsiness
  • Headache
  • Increased sweating or flushing
  • Loss of appetite, loss of weight
  • Loss of sexual desire, erectile, or orgasm dysfunction
  • Nausea
  • Weakness or tiredness
  • Weight gain or weight loss

MAJOR CAUTIONS (more…)

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Anxiety Drugs Selective Serotonin Reuptake Inhibitors (SSRIs)

Sunday, May 30th, 2010

Anxiety Drugs Selective Serotonin Reuptake Inhibitors (SSRIs)

  • Citalopram (Celexa)
  • Escitalopram (Lexapro)
  • Fluoxetine tablets or capsules (Prozac)
  • Fluvoxamine (Luvox)
  • Paroxetine (Paxil, Paxil CR, Pexeva)
  • Sertraline (Zoloft)

HOW DO THESE DRUGS WORK?

These drugs block the reuptake of serotonin so that it remains active in the brain longer before being broken down and reabsorbed. The neurotransmitter serotonin gives the sensation of well-being.

WHAT ARE THE BENEFITS?

Improvement in depression, generally with fewer side effects than other categories of antidepressants. SSRIs have fewer side effects than the tricyclic antidepressants and monoamine oxidase (MAO) inhibitors, which we discuss below. Unlike MAO inhibitors, SSRIs do not interact with the amino acid tyramine found in certain foods. Also, SSRIs do not cause orthostatic hypotension and heart rhythm disturbances, as tricyclic antidepressants can. SSRIs are often the first-line pharmaceutical choice for depression.

POTENTIAL SIDE EFFECTS

  • Nausea
  • Diarrhea
  • Agitation
  • Insomnia
  • Decreased sexual desire
  • Delayed orgasm or inability to have an orgasm

MAJOR CAUTIONS

Tremors can be a side effect of SSRIs. Serotonergic syndrome, in which serotonin levels are too high, is a serious but rare condition associated with the use of SSRIs. Symptoms can include high fevers, seizures, and heart rhythm disturbances. (more…)

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Anxiety Drugs Benzodiazepines

Sunday, May 23rd, 2010

Anxiety Drugs Benzodiazepines

  1. Alprazolam Extended-Release (Xanax XR)
  2. Alprazolam oral solution (Alprazolam Intensol)
  3. Alprazolam tablets (Niravam, Xanax)
  4. Chlordiazepoxide (Libritabs, Librium)
  5. Clonazepam (Klonopin)
  6. Clorazepate (Tranxene, Tranxene T, Tranxene-SD)
  7. Diazepam (Valium)
  8. Lorazepam (Ativan)
  9. Oxazepam (Serax)

HOW DO THESE DRUGS WORK?

Benzodiazepines enhance the effect of the neurotransmitter known as gammaaminobutyric acid (GABA). They bind to GABA receptors, which slows down the activity of nerve cells. This causes an inhibitory and relaxant effect.

WHAT ARE THE BENEFITS?

These drugs provide rapid relief for those with anxiety. (more…)

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Antacid and Reflux Drugs: Foam Barriers

Saturday, May 1st, 2010

Antacid and Reflux Drugs: Foam Barriers

Aluminum hydroxide gel, magnesium trisilicate, and alginate (Gaviscon)

HOW DO THESE DRUGS WORK?

Foam barriers are tablets composed of an antacid and a foaming agent. Foam barriers provide a unique form of treatment for GERD. As the tablet disintegrates and reaches the stomach, it turns into foam that floats on top of the liquid contents of the stomach. The foam forms a physical barrier to the reflux of liquid.At the same time, the antacid bound to the foam neutralizes acid that comes in contact with the foam. The tablets are best taken after meals (when the stomach is distended) and when you are lying down, both times when reflux is more likely to occur.

WHAT ARE THE BENEFITS?

Foam barriers are not often used as the first or only treatment for GERD. Rather, they are added to other drugs for GERD when the other drugs are not adequately effective in relieving symptoms.

POTENTIAL SIDE EFFECTS

- Loss of appetite
- Constipation or diarrhea
- Weakness
- Headache

MAJOR CAUTIONS

Since this medication contains aluminum and magnesium, consult with your doctor first before using it if you have kidney disease. Also, those on a sodium-restricted diet should not take Gaviscon without consulting with their doctor first.

KNOWN DRUG INTERACTIONS (more…)

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Antacid and Reflux Drugs: Pro-motility Drugs

Tuesday, April 27th, 2010

Antacid and Reflux Drugs: Pro-motility Drugs

Metoclopramide (Reglan)

HOW DOES THIS DRUG WORK?

Metoclopramide (Reglan) is one in the class of pro-motility drugs approved for GERD. It works by mildly increasing the pressure in the lower esophageal sphincter, which strengthens contractions of the esophagus and speeds up emptying of the stomach. All these actions are thought to reduce reflux. It is most effective when taken 30 minutes before meals.

WHAT ARE THE BENEFITS?

This drug reduces symptoms of GERD. It is not very effective for treating the symptoms of GERD, however, and is usually prescribed as an addition to other GERD medications or for those who do not respond to common GERD medications.

POTENTIAL SIDE EFFECTS

- Nausea
- Diarrhea
- Headache
- Dizziness
- Drowsiness
- Dry mouth
- Restlessness
- Involuntary movements of the eyes/face/limbs
- Muscle spasms
- Trembling of the hands
- Personality changes such as depression or thoughts of suicide
- High fever
- Sweating
- Muscle stiffness
- Confusion
- Unusually fast heartbeat

MAJOR CAUTIONS (more…)

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Antacid and Reflux Drugs: Proton Pump Inhibitors

Saturday, April 24th, 2010

Antacid and Reflux Drugs: Proton Pump Inhibitors

Lansoprazole (Prevacid)
Omeprazole (Prilosec)
Pantoprazole (Protonix)
Rabeprazole (Aciphex)
Esomeprazole (Nexium)

HOW DO THESE DRUGS WORK?

Proton pump inhibitors (PPIs) block the secretion of acid into the stomach by the acid-secreting cells with a different mechanism than H2 blockers. More specifically, PPIs inhibit the proton pump of the parietal cells (the stomach

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Antacid and Reflux Drugs: Antacids

Thursday, April 15th, 2010

Antacid and Reflux Drugs: Antacids

  1. Aluminum and magnesium hydroxide (Maalox,Mylanta)
  2. Aluminum carbonate gel (Basajel)
  3. Aluminum hydroxide (Amphojel, AlternaGEL)
  4. Calcium carbonate (Tums, Titralac, Calcium-Rich Rolaids)
  5. Magnesium hydroxide (Phillips

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